Protective Effects of Cudrania tricuspidata Against Helicobacter pylori -Induced Inflammation in C57BL/6 Mice.

modulates the host inflammatory response, resulting in chronic gastritis, which contributes to gastric cancer pathogenesis. We verified the effect of on infection by inhibiting -induced inflammatory activity. Five-week-old C57BL/6 mice ( = 8) were administered leaf extract (10 or 20 mg/kg per day) for 6 weeks. An invasive test (campylobacter-like organism [CLO]) and noninvasive tests (stool antigen test [SAT] and antibody enzyme-linked immunosorbent assay) were performed to confirm the eradication of . To evaluate the anti-inflammatory effect of pro-inflammatory cytokines levels and inflammation scores were measured in mouse gastric tissue. significantly decreased the CLO score and immunoglobulin G antibody optical density levels at both 10 and 20 mg/kg per day doses ( < .05). decreased the antibody levels in a concentration-dependent manner, increased negative responses to SAT by up to 37.5%, and inhibited the pro-inflammatory cytokines interleukin (IL; IL-1, IL-6, 1L-8, and tumor necrosis factor alpha). also relieved gastric erosions and ulcers and significantly reduced the inflammation score ( < .05). We measured rutin in extract as a standard for high-performance liquid chromatography. leaf extract showed anti- activity through the inhibition of inflammation. Our findings suggest that leaf extract is potentially an effective functional food material against .