A comparative study of antibody response, virus neutralization efficiency & metabolites in SARS-CoV-2-infected adults & children.

Renu Sudhakar,Suchitra Dontamala,Thrilok Chander Bingi, Somesh Gorde, Abhipsa Panda,Zeba Rizvi,G Srinivas Reddy,Savita Kaswan,Manish Bhattacharjee,Deepak Kumar, M Angel Nivya,Raja Rao Mesipogu, K S Varadarajan, Anant B Patel,Divya Gupta,Krishnan H Harshan,Karthik Bharadwaj Tallapaka,Puran Singh Sijwali

The Indian journal of medical research（2023）

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摘要

Our results reflect the complexity of human immune response and metabolome to SARS-CoV-2 infection. While innate and cellular immune responses are likely to be a major determinant of disease severity and protection, antibodies to multiple viral proteins likely affect COVID-19 pathogenesis. In children, not adults, lower seropositivity rate for spike was associated with disease severity.

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Antibody response - corona virus - COVID-19 - nucleocapsid - serosurvey - SARS-CoV-2 - spike

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