Diagnostic utility of FOXO1 immunohistochemistry for rhabdomyosarcoma classification.

Cooper D Rutland, Jodi Gedallovich,Aihui Wang,Sabrina Zdravkovic,Sushama Varma,Jason L Hornick,Gregory W Charville

Histopathology（2023）

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摘要

Taken together, our findings suggest that FOXO1 immunohistochemistry is a highly sensitive and relatively specific surrogate marker of the PAX3/7::FOXO1 fusion oncoprotein in rhabdomyosarcoma. Cytoplasmic immunoreactivity, expression in nonneoplastic tissues, and limited nuclear staining of nonalveolar rhabdomyosarcomas represent potential pitfalls in interpretation.

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关键词

FOXO1,fusion oncoprotein,immunohistochemistry,rhabdomyosarcoma,sarcoma,soft tissue tumours

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