Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.

Johannes Soltwedel,Theresa Suckert,Elke Beyreuther,Moritz Schneider,Marc Boucsein,Elisabeth Bodenstein, Sindi Nexhipi, Liane Stolz-Kieslich,Mechthild Krause,Cläre von Neubeck,Robert Haase,Armin Lühr,Antje Dietrich

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology（2023）

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摘要

Comprehending cellular changes of radiation-induced brain injury is crucial to prevent and treat the pathology. We provide a unique open dataset of proton-irradiated mouse brains consisting of medical imaging, radiation dose simulations, and large-scale microscopy images, all registered into a common coordinate system. This allows dose-dependent analyses on single-cell level.

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