Distinct Mechanisms Responsible for the Increase in Glucose Production and Ketone Formation Caused by Empagliflozin in T2DM Patients.

Siham Abdelgani, Ahmad Khatab,John Adams,Mohamed Abu-Farha, Guisepe Daniele,Fahd Al-Mulla,Stefano Del Prato,Ralph A DeFronzo,Muhammad Abdul-Ghani

Diabetes care（2023）

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摘要

The decrease in plasma insulin and increase in plasma glucagon concentration caused by empagliflozin is responsible for the increase in plasma FFA concentration and ketone production. The increase in EGP caused by empagliflozin is independent of the change in plasma insulin or glucagon concentrations and is likely explained by the increase in NE turnover.

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关键词

empagliflozin,t2dm patients,glucose production,ketone formation

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