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Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection.

Xenotransplantation(2023)

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XenotransplantationVolume 30, Issue 2 e12796 LETTER TO THE EDITOR Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection Mohamed B. Ezzelarab, Corresponding Author Mohamed B. Ezzelarab [email protected] orcid.org/0000-0002-3919-5250 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA Correspondence Mohamed B. Ezzelarab, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA. Email: [email protected]Search for more papers by this authorHidetaka Hara, Hidetaka Hara orcid.org/0000-0002-4179-7365 College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan, ChinaSearch for more papers by this authorDavid Ayares, David Ayares Revivicor, Blacksburg, VA, USASearch for more papers by this authorDavid K.C. Cooper, David K.C. Cooper Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USASearch for more papers by this author Mohamed B. Ezzelarab, Corresponding Author Mohamed B. Ezzelarab [email protected] orcid.org/0000-0002-3919-5250 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA Correspondence Mohamed B. Ezzelarab, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA. Email: [email protected]Search for more papers by this authorHidetaka Hara, Hidetaka Hara orcid.org/0000-0002-4179-7365 College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan, ChinaSearch for more papers by this authorDavid Ayares, David Ayares Revivicor, Blacksburg, VA, USASearch for more papers by this authorDavid K.C. Cooper, David K.C. Cooper Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USASearch for more papers by this author First published: 28 February 2023 https://doi.org/10.1111/xen.12796Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1Denner J. Systemic inflammation in xenograft recipients (SIXR) or undetected PCMV/PRV transmission? Xenotransplantation. 2022:e12788. https://doi.org/10.1111/xen.12788 2Ezzelarab MB, Ekser B, Azimzadeh A, et al. Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation. 2015; 22(1): 32- 47. https://doi.org/10.1111/xen.12133 3Li J, Hara H, Wang Y, Esmon C, Cooper DKC, Iwase H. Evidence for the important role of inflammation in xenotransplantation. J Inflamm (Lond). 2019; 16: 10. https://doi.org/10.1186/s12950-019-0213-3 4Griffith BP, Goerlich CE, Singh AK, et al. Genetically Modified Porcine-to-Human Cardiac Xenotransplantation. N Engl J Med. 2022; 387(1): 35- 44. https://doi.org/10.1056/NEJMoa2201422 5Cooper DKC, Yamamoto T, Hara H, Pierson RN, 3rd. The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome? Xenotransplantation. 2022; 29(4):e12771. https://doi.org/10.1111/xen.12771 6Mueller NJ, Barth RN, Yamamoto S, et al. Activation of cytomegalovirus in pig-to-primate organ xenotransplantation. J Virol. 2002; 76(10): 4734- 4740. https://doi.org/10.1128/jvi.76.10.4734-4740.2002 7Mueller NJ, Sulling K, Gollackner B, et al. Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation. Am J Transplant. 2003; 3(9): 1057- 1064. https://doi.org/10.1034/j.1600-6143.2003.00192.x 8Mueller NJ, Kuwaki K, Dor FJ, et al. Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation. Transplantation. 2004; 78(10): 1449- 1453. https://doi.org/10.1097/01.tp.0000141361.68446.1f 9Mueller NJ, Livingston C, Knosalla C, et al. Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation. J Infect Dis. 2004; 189(9): 1628- 1633. https://doi.org/10.1086/383351 10Mueller NJ, Ezzelarab M, Buhler L, Haeberli L, Ayares D, Cooper DK. Monitoring of porcine and baboon cytomegalovirus infection in xenotransplantation. Xenotransplantation. 2009; 16(6): 535- 536. https://doi.org/10.1111/j.1399-3089.2009.00536.x 11Gollackner B, Mueller NJ, Houser S, et al. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. Transplantation. 2003; 75(11): 1841- 1847. https://doi.org/10.1097/01.TP.0000065806.90840.C1 12Yamada K, Tasaki M, Sekijima M, et al. Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model. Transplantation. 2014; 98(4): 411- 418. https://doi.org/10.1097/TP.0000000000000232 13van Dam-Mieras MC, Muller AD, van Hinsbergh VW, Mullers WJ, Bomans PH, Bruggeman CA. The procoagulant response of cytomegalovirus infected endothelial cells. Thromb Haemost. 1992; 68(3): 364- 370 14Sutherland MR, Raynor CM, Leenknegt H, Wright JF, Pryzdial EL. Coagulation initiated on herpesviruses. Proc Natl Acad Sci U S A. 1997; 94(25): 13510- 13514. https://doi.org/10.1073/pnas.94.25.13510 Volume30, Issue2March/April 2023e12796 ReferencesRelatedInformation
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xenotransplant recipient,systemic inflammation,infection
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