A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization.

Xiaozhi Xi,Guokai Xiao, Guiqi An,Lin Liu,Xiaochun Liu, Peiyu Hao,Jennifer Yiyang Wang, Dandan Song,Wengong Yu,Yuchao Gu

Frontiers in immunology（2023）

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摘要

Our results show that shark single-domain antibodies targeting OGT can be used for in vitro detection and intracellular co-localization of OGT, providing a powerful tool for the study of OGT and O-GlcNAcylation.

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关键词

ELISA,O-GlcNAc,OGT,Shark VNAR,computer simulation,immunofluorescence

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