Effects of ABCB1 and ABCG2 Polymorphisms on the Pharmacokinetics of Abemaciclib Metabolites (M2, M20, M18).

Akimitsu Maeda,Hitoshi Ando,Kei Irie,Naoya Hashimoto,Jun-Ichi Morishige,Shoji Fukushima,Hiromichi Ebi, Kosaku Uchida,Hiroji Iwata,Masataka Sawaki

Anticancer research（2023）

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摘要

The ABCB1 2677G>T/A polymorphism may influence tolerance to abemaciclib in breast cancer patients by affecting the pharmacokinetics of the agent and its active metabolites.

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关键词

ABCB1,ABCG2,Abemaciclib,metabolites,polymorphisms

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