Discovery of Targets for Immune-Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha.

Avinash Sahu,Xiaoman Wang,Phillip Munson,Jan P G Klomp,Xiaoqing Wang,Shengqing Stan Gu,Ya Han,Gege Qian,Phillip Nicol,Zexian Zeng,Chenfei Wang,Collin Tokheim,Wubing Zhang,Jingxin Fu,Jin Wang,Nishanth Ulhas Nair, Joost A P Rens, Meriem Bourajjaj,Bas Jansen, Inge Leenders,Jaap Lemmers, Mark Musters, Sanne van Zanten, Laura van Zelst, Jenny Worthington,Jun S Liu,Dejan Juric,Clifford A Meyer,Arthur Oubrie,X Shirley Liu,David E Fisher,Keith T Flaherty

Cancer discovery（2023）

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摘要

BipotentR presents resources for evaluating patient response and identifying targets for drugs that can kill tumors through multiple mechanisms concurrently. Inhibition of the topmost candidate target killed tumors by suppressing energy metabolism and effects on two immune mechanisms. This article is highlighted in the In This Issue feature, p. 517.

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receptor,alpha,immune-metabolic

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