"Fruit In A Tooth" - A Rare Non - Syndromic Anomaly-2 Rare Case Reports with a Genetic Analysis

JOURNAL OF INDIAN ACADEMY OF ORAL MEDICINE AND RADIOLOGY(2022)

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Abstract
Tooth agenesis is one of the most common developmental anomalies affecting function and aesthetics. Genetic mutations cause non-syndromic tooth agenesis and involve the interaction of genes of tooth epithelium and mesenchyme odontogenesis. This article is the first in the literature to present non-syndromic cases of two siblings reported with mulberry molars, morphological changes in teeth (hypodontia and microdontia), and a genetic study performed to substantiate the involvement of Paired box gene 9 in tooth agenesis and morphogenesis.
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Key words
Developmental defect,genetic mutation,mulberry molar,PAX9
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