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Synthesis of 3-deazaneplanocin A analogs and their antiviral activity against RNA-viruses

Se Myeong Choi,Yeon Jin An,Eun Rang Choi,Ye Eun Nam,Eun Woo Seo, Changhyun Kang,Soo Bin Ahn,Uk-Il Kim,Meehyein Kim,Kyungjin Kim,Jong Hyun Cho

JOURNAL OF MOLECULAR STRUCTURE（2023）

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Abstract
•The chiral 1-hydroxy-cyclopentenyl analogs (22a-b) were synthesized in the multi-gram scale from D-ribose.•New N7-/N9-2,6-dihalo-3-deazaneplanocin and N7-6-azido-3-deazaneplanocin analogs were prepared.•Novel N9-2,6-dibromo-3-deazaneplanocin (44a) exhibited the most potent activity against flu a (H1N1) with EC50 value of 7.0 μM in vitro.
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Cyclopentenol analogs,Nucleosides,3-Deazapurine analogs,3-deazaneplanocin A,Influenza A virus,Dengue virus,Antiviral agents
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