Effect of stereocomplex formation between enantiomeric poly(l,ulactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution

The effect of crystallization of a hydrophobic poly(lactide) block on the self-organization of biocompatible and biodegradable PEO) copolymers in a dilute aqueous solution has been investigated. It was demonstrated that the co-crystallization of poly(L,L-lactide) [P(L,L)LA] and poly(D,D-lactide) [P(D,D)LA] chains under equimolar mixing of P(L,L)LA46-b-PEO113 and P(D,D)LA56-b-PEO113 copolymers resulted in the formation of stable and spontaneously water-redispersible stereo complex micelles with semicrystalline P(L,L)LA/P(D,D)LA cores. It was shown that the P(L,L)LA46 / P(D,D)LA56-b-PEO113 stereocomplex micelles produced by dialysis can be potential vehicles for the anticancer agent oxaliplatin.