Curcumin nanoparticles impregnated collagen/demineralized bone matrix/olive leaves extract biocomposites as a potential bone implant: Preparation, characterization, and biocompatibility

In this study, nanoceramic composite (NCC) was developed using the Type I collagen (COLL), demineralized bone matrix (DBM), olive leaves extract (OLE), and curcumin nanoparticles (Cu-NPs). The study evaluates the possibility of using this NCC as a bone tissue engineering material. The developed NCC was characterized by its mechanical, physicochemical, and biocompatibility properties. The NCC possessed excellent mechanical properties. A biocompatibility study was proved in the MG-63 osteoblast cell line on NCC. The study introduced a method for producing a functionalized implant, such as bone tissue engineering material, using natural resources. In vitro bone healing abilities of NCC were demonstrated in our investigation. As a result, NCC could be suggested as a source of bone graft and healing agents. Graphical abstract