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Carbon Dots-Based Nanozyme for Drug-Resistant Lung Cancer Therapy by Encapsulated Doxorubicin/siRNA Cocktail.

Hailing Yu,Kexin Tang,Zeyu Cai,Xi Lin,Yongquan Huang,Ting Yu,Qianqian Zhang, Qiang Wang,Lili Wu,Lei Yang,Hong Shan,Hui Luo

International journal of nanomedicine（2023）

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Abstract
Taken together, we uncover the potential role of CDs with a combination of siRNA and chemotherapeutics in overcoming chemoresistance of lung cancer by suppressing MRP1 and oxidation of GSH. Our findings imply its potential of antagonizing chemoresistance to enhance therapeutic efficiency of doxorubicin in clinical practices of lung cancer treatment.
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Key words
carbon dots,chemoresistance,co-delivery,siRNA
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