Self-assembly of protein-DNA superstructures for alkaline phosphatase detection in blood.

Yangyang Chang,Qian Zhang,Wei Xue,Yanfang Wu,Yi Liu,Meng Liu

Chemical communications (Cambridge, England)（2023）

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摘要

We designed a paper-based analytical device by integrating horseradish peroxidase (HRP)-encapsulated 3D DNA for visual detection of alkaline phosphatase (ALP). This device allows on-paper sample pre-treatment, target recognition and signal readout, enabling simple (without additional pre-treatment of blood samples) and rapid (within 23 min) determination of ALP in clinical samples.

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关键词

alkaline phosphatase detection,protein–dna superstructures,self-assembly

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