The risk of radiation-induced neurocognitive impairment and the impact of sparing the hippocampus during pediatric proton cranial irradiation.
Acta oncologica (Stockholm, Sweden)（2023）
Abstract
We present estimates of potential clinical benefit in terms of neurocognitive impairment and demonstrate the possibility of considerably reducing neurocognitive adverse effects, minimally compromising target coverage locally using HS-IMPT.
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Key words
Neurocognitive impairment,craniospinal irradiation,hippocampal avoidance,normal tissue complication probability,pediatric hippocampus,tumor control probability
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