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Factors Influencing the Efficacy of Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury.

Elisha Purcell,Timothy Nguyen,Madeleine Smith,Tayla Penny,Madison C B Paton,Lindsay Zhou,Graham Jenkin,Suzanne L Miller,Courtney A McDonald,Atul Malhotra

Stem cells translational medicine（2023）

Cited 2|Views28
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Abstract
Preclinical evidence suggests UCBCs to show greater efficacy in the injury model of IVH compared to HI, the use of UCB-MSCs compared to UCB-MNCs and the use of local administrative routes compared to systemic routes in animal models of perinatal brain injury. Further research is needed to improve certainty of evidence and address knowledge gaps.
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Key words
brain injuries,cord blood stem cell transplantation,fetal blood,perinatal care,systematic review
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