KNSTRN , a Poor Prognostic Biomarker, Affects the Tumor Immune Microenvironment and Immunotherapy Outcomes in Pan-Cancer.

Kinetochore-localized astrin- (SPAG5-) binding protein () is mainly involved in mitosis. Somatic mutations in are known to lead to the occurrence and development of certain tumors. However, the role of in the tumor immune microenvironment (TIME) as a tumor prognostic biomarker and potential therapeutic target has not been clarified. Accordingly, in this study, we aimed to investigate the role of in the TIME. mRNA expression, cancer patient prognosis, and correlations between expression and immune component infiltration were analyzed using Genotype-Tissue Expression, The Cancer Genome Atlas, Cancer Cell Line Encyclopedia, Human Protein Atlas, ImmuCellAI, TIMER2.0, and KM-Plotter. The Genomics of Drug Sensitivity in Cancer database was used to evaluate the relationship between expression and the half maximal inhibitory concentration (IC50) of several anticancer drugs, and gene set variation analysis was performed. Data were visualized using R version 4.1.1. expression was upregulated in the majority of cancers and was associated with a worse prognosis. Additionally, expression was highly correlated with the infiltration of multiple immune components in the TIME and was related to a poor prognosis in tumor patients receiving immunotherapy. expression was also positively correlated with the IC50 of various anticancer drugs. In conclusion, may be a significant prognostic biomarker and promising target for oncotherapy in numerous cancers.