Infection prevention and control programme and COVID-19 measures: Effects on hospital-acquired infections in patients with cirrhosis.

Simone Di Cola,Jakub Gazda,Lucia Lapenna,Giancarlo Ceccarelli,Manuela Merli

JHEP reports : innovation in hepatology（2023）

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摘要

Infections are a life-threatening problem for patients with liver cirrhosis. Moreover, hospital-acquired infections are even more alarming owing to the high prevalence of multidrug-resistant bacteria. This study analysed a large cohort of hospitalised patients with cirrhosis from three different periods. Unlike in the first period, an infection prevention programme was applied in the second period, reducing the number of hospital-acquired infections and containing multidrug-resistant bacteria. In the third period, we imposed even more stringent measures to minimise the impact of the COVID-19 outbreak. However, these measures did not result in a further reduction in hospital-acquired infections.

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关键词

ALD, alcoholic liver disease,Antibiotic resistance,Antimicrobial stewardship,BB, beta-blockers,Bacterial infections,C19MC, COVID-19 measures cohort,CA, community acquired,COVID-19, coronavirus disease 2019,CRP, C-reactive protein,EATF, empiric antibiotic treatment failure,Empiric antibiotic failure,HAI, hospital-acquired infection,HCA, healthcare-associated,IPCC, infection prevention and control cohort,IPCP, infection prevention and control programme,Liver cirrhosis,MAP, mean arterial pressure,MDR, multidrug-resistant,MELD, model for end-stage liver disease,Multidrug-resistant bacteria,NASH, non-alcoholic steatohepatitis,Nosocomial infections,OR, odds ratio,PDR, pandrug-resistant,PPI, proton pump inhibitor,SARS-CoV-2,SBP, spontaneous bacterial peritonitis,SMC, standard measures cohort,UTI, urinary tract infection,WBC, white blood cell,XDR, extensively drug-resistant

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