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HLA-DQ2 is associated with anti-drug antibody formation to infliximab in patients with immune-mediated inflammatory diseases.

Marthe Kirkesaether Brun,Kristin Hammersbøen Bjørlykke,Marte K Viken,Grethe-Elisabeth Stenvik,Rolf A Klaasen,Johanna E Gehin,David John Warren,Joseph Sexton,Øystein Sandanger,Tore K Kvien,Cato Mørk,Espen A Haavardsholm,Jørgen Jahnsen,Guro Løvik Goll,Benedicte A Lie,Nils Bolstad,Kristin Kaasen Jørgensen,Silje Watterdal Syversen

Journal of internal medicine（2023）

Cited 1|Views39
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Abstract
A genome-wide significant association between two HLA-DQ2 haplotypes and the risk of ADAb formation to infliximab was identified, suggesting that HLA-DQ2 testing may facilitate personalised treatment decisions.
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Key words
autoimmune disease,gastroenterology,genetics,immunology,immunosuppressive treatment,rheumatology
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