A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin.

Jiyong Liang,Dexing Fang,Joy Gumin,Hinda Najem,Moloud Sooreshjani,Renduo Song,Aria Sabbagh,Ling-Yuan Kong,Joseph Duffy,Irina V Balyasnikova,Seth M Pollack,Vinay K Puduvalli,Amy B Heimberger

Cancers（2023）

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摘要

These data propose CAR-induced autophagy as a mechanism counteracting CAR-induced trogocytosis and provide a new strategy to innovate high-performance CARs through pharmacological facilitation of T cell-induced tumor death.

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关键词

autophagy,chimeric antigen receptor T cells,epidermal growth factor receptor variant III,glioblastoma,phagocytosis,trogocytosis

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