Discovery of pterostilbene analogs as novel NLRP3 inflammasome inhibitors for potential treatment of DSS-induced colitis in mice
Bioorganic Chemistry(2023)
摘要
•Novel pterostilbene analogs compounds were synthesized.•Compound D22 inhibits inflammatory factor IL-1β secretes by targeting NLRP3 protein and shows high anti-inflammatory activity.•In vivo experiments showed that D22 had a good therapeutic effect on DSS-induced acute colitis in mice.
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关键词
NLRP3 inflammasome,Inhibitor,Pterostilbene derivatives,IBD
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