Bone marrow niche chemoprotection of metastatic solid tumors mediated by CYP3A4.

Gabriel Ghiaur,Kenneth C Valkenburg,Christopher Esteb,Alexander Ambinder,Philip H Imus,Kenneth J Pienta,Richard J Jones

Cancer（2023）

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摘要

These results suggest that, similar to observations from hematologic malignancies, the BM microenvironment, through expression of CYPs, creates a sanctuary site from chemotherapy for metastatic solid tumors. Targeting these sanctuaries holds promise for eradicating bone metastasis in solid tumors.

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关键词

bone marrow microenvironment,cancer stem cells,cytochrome P450 3A4 (CYP3A4),drug resistance,metastatic disease,prostate cancer

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