External Evaluation of Population Pharmacokinetic Models of Methotrexate for Model-Informed Precision Dosing in Pediatric Patients with Acute Lymphoid Leukemia.
Pharmaceutics（2023）
Abstract
Some of the published models showed reasonably low levels of bias but had some problems with imprecision, and extensive evaluation is needed before model application in clinical practice.
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Key words
acute lymphoid leukemia,children,external validation,methotrexate,population pharmacokinetics
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