Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study.

Foteini Christidi,Georgios D Argyropoulos,Efstratios Karavasilis,Georgios Velonakis,Vasiliki Zouvelou,Panagiotis Kourtesis,Varvara Pantoleon,Ee Ling Tan,Ariadne Daponte,Stavroula Aristeidou,Sofia Xirou,Panagiotis Ferentinos,Ioannis Evdokimidis,Michail Rentzos,Ioannis Seimenis,Peter Bede

Life (Basel, Switzerland)（2023）

Cited 8|Views19

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Abstract

Hippocampal 1H-MRS may not only contribute to a better academic understanding of extra-motor disease burden in ALS, but given its sensitive correlations with validated clinical metrics, it may serve as practical biomarker for future clinical and clinical trial applications. Neuroimaging protocols in ALS should incorporate MRS in addition to standard structural, functional, and diffusion sequences.

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Key words

amyotrophic lateral sclerosis,grey matter,hippocampus,magnetic resonance spectroscopy,memory,metabolites,perforant pathway,tractography,white matter

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