Structure and Microbiological Activity of 1 H -benzo[ d ]imidazole Derivatives.
International journal of molecular sciences(2023)
Abstract
Three new crystal structures of 1-benzo[]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs.
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Key words
1H-benzo[d]imidazole derivatives,ADME,X-ray,antimicrobial activity,crossing the blood–brain barrier,structure–activity relationship
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