Effectiveness and safety of tenofovir alafenamide in children and adolescents living with HIV: a systematic review.

John O'Rourke,Claire L Townsend,Edith Milanzi,Intira Jeannie Collins,Hannah Castro,Ali Judd,Marissa Vicari,Julie Jesson,Valériane Leroy,Martina Penazzato,Françoise Renaud

Journal of the International AIDS Society（2023）

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摘要

Four single-arm trials were identified in this systematic review, with initial evidence suggesting good viral suppression and no obvious safety concerns in children and adolescents on TAF-containing regimens over 24-48 weeks. However, further comparative and longer-term safety data are needed in children and adolescents, including on weight and metabolic changes.

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关键词

HIV,children,drug-related side effects and adverse reactions,systematic review,tenofovir,treatment outcome

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