Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea irritable bowel syndrome.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society（2023）
Abstract
These data support the multifactorial IBS pathogenesis in which organic and psychological factors interact. An active role by VD, 5-HT, and BDNF in affecting the clinical and biochemical profiles in IBS-D(S+) patients may be conceivable. Therefore, the routine VD estimation and the assay of circulating levels of 5-HT and BDNF could be considered a new approach for managing these patients.
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Key words
5-HT,BDNF,abdominal pain,gastrointestinal symptom profile,inflammation,irritable bowel syndrome,vitamin D
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