Integrating in Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254).

Konstantinos Stamatopoulos,Paola Ferrini,Dung Nguyen,Ying Zhang,James M. Butler, Jon Hall,Nena Mistry

PHARMACEUTICS（2023）

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关键词

PBPK modelling,PBBM modelling,biopharmaceutics,food effect,BCS IV,biorelevant media,in vitro,dissolution,permeability,MDCK cell line,FaSSIF,FeSSIF,Simcyp((R))

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