Association of Proton Pump Inhibitor Use With Risk of Acquiring Drug-Resistant Enterobacterales.

Roel P J Willems,Martijn C Schut, Anna M Kaiser,Thomas H Groot,Ameen Abu-Hanna,Jos W R Twisk,Karin van Dijk,Christina M J E Vandenbroucke-Grauls

JAMA network open（2023）

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摘要

In this study, after careful control for confounding and sensitivity analyses, PPI use was associated with increases in the risk of acquiring ESBL- or carbapenemase-producing Enterobacterales among adult hospitalized patients. These findings emphasize the need for judicious use of PPIs.

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proton pump inhibitor use,drug-resistant

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