Development of a candidate reference measurement procedure by ID-LC-MS/MS for total tau protein measurement in cerebrospinal fluid (CSF).

Chiara Giangrande,Hélène Vaneeckhoutte,Amandine Boeuf,Béatrice Lalere,Christophe Hirtz,Sylvain Lehmann,Milena Quaglia,Vincent Delatour

Clinical chemistry and laboratory medicine（2023）

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摘要

The candidate RMP will pave the road towards global standardization of CSF t-tau measurements. Together with commutable Certified Reference Materials (CRMs), it will allow evaluating and improving the accuracy and comparability of results provided by IAs.

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关键词

CSF,ID LC-MS/MS,SI-traceability,neurodegenerative diseases,reference method,t-tau

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