Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats.

Takuya Koizumi,Masaya Watanabe,Takashi Yokota,Masumi Tsuda,Haruka Handa, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta,Hiroyuki Natsui,Takahide Kadosaka,Taro Koya,Motoki Nakao,Hikaru Hagiwara,Rui Kamada,Taro Temma,Shinya Tanaka,Toshihisa Anzai

Frontiers in cardiovascular medicine（2023）

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摘要

These data suggest that empagliflozin has a cardioprotective effect, at least in part, by reducing mitochondrial ROS generation through AMPK signaling pathways in the atrium of diabetic rats. This suggests that empagliflozin might suppress the development of AF in T2DM.

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关键词

SGLT2 inhibitor,diabetes,empagliflozin,mitochondria,reactive oxygen species

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