Topological network properties of resting-state functional connectivity patterns are associated with metal mixture exposure in adolescents.

Azzurra Invernizzi,Elza Rechtman,Kristie Oluyemi,Stefano Renzetti,Paul Curtin,Elena Colicino,Claudia Ambrosi,Lorella Mascaro,Alessandra Patrono,Daniele Corbo,Giuseppa Cagna,Roberto Gasparotti,Abraham Reichenberg,Cheuk Y Tang,Donald R Smith,Donatella Placidi,Roberto G Lucchini,Robert O Wright,Megan K Horton

Frontiers in neuroscience（2023）

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摘要

Our results suggest that exposure to this metal mixture during adolescence reduces the efficiency of integrating information in brain networks at both local and global levels, informing potential neural mechanisms underlying the developmental toxicity of metals. Results further suggest these associations are due to combined joint effects to different metals, rather than to a single metal.

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关键词

exposure,global and local efficiency,graph theory,neurotoxic metals,resting state–fMRI,topological network properties

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