Rapid Equilibrium Dialysis, Ultrafiltration or Ultracentrifugation? Evaluation of Methods to Quantify the Unbound Fraction of Substances in Plasma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS（2023）
Key words
Toxicokinetics,Fraction unbound(fu),Plasma protein-binding (PPB),In vitro to in vivo extrapolation (IVIVE)
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