Clinical Next-Generation Sequencing Panels Reveal Molecular Differences Between Merkel Cell Polyomavirus-Negative Merkel Cell Carcinomas and Neuroendocrine Carcinomas.
American journal of clinical pathology(2023)
摘要
High tumor mutational burden and UV signature, as well as the presence of NF1 and PIK3CA mutations, are supportive of MCPyV-negative MCC, whereas KEAP1, STK11, and KRAS mutations are supportive of NEC in the appropriate clinical context. Although rare, the presence of a gene fusion is supportive of NEC.
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关键词
Fusion analyses,Merkel cell carcinoma,Molecular analyses,Neuroendocrine carcinoma,Next-generation sequencing,UV signature
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