Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier.

Caterina Squarci,Pasquale Bianco,Massimo Reconditi,Irene Pertici,Marco Caremani,Theyencheri Narayanan,Ádám I Horváth,András Málnási-Csizmadia,Marco Linari,Vincenzo Lombardi,Gabriella Piazzesi

Proceedings of the National Academy of Sciences of the United States of America（2023）

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摘要

Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere, responsible for passive force development at sarcomere length (SL) above the physiological range (>2.7 μm). The role of titin at physiological SL is unclear and is investigated here in single intact muscle cells of the frog ( Rana esculenta-1

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关键词

muscle regulation,myosin filament activation,skeletal muscle,striated muscle,titin

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