Possible genetical predictors of efficacy and safety of budesonide-MMX in patients with mild-to-moderate ulcerative colitis, and safety comparison with methylprednisolone.

Tamás Resál,Katalin Mangó,Péter Bacsur,Kata Szántó,Daniella Pigniczki,Csilla Keresztes,Mariann Rutka,Anita Bálint,Ágnes Milassin,Renáta Bor,Anna Fábián,Zoltán Szepes,Klaudia Farkas,Katalin Monostory,Tamás Molnár

Expert opinion on drug safety（2023）

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Abstract

CYP genotypes can affect the efficacy of budesonide-MMX; however, further studies would be needed with analyses of gene expression. Although budesonide-MMX is safer than methylprednisolone, due to glucocorticoid-related side effects, admission should require greater precaution.

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Key words

CYP genotype,budesonide-MMX,cytochrome enzyme,methylprednisolone,ulcerative colitis

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