Patient-centered outcomes in the POLO study of active maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer.

Hedy L Kindler,Hyun Kyoo Yoo,Robert Hettle,Karen Y Cui,Seongjung Joo,Gershon Y Locker,Talia Golan

Cancer（2023）

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摘要

These results support the previous findings that maintenance olaparib significantly improves PFS relative to placebo without compromising HRQOL and demonstrate that the clinically meaningful benefits of olaparib persist even when symptoms of toxicity are considered.

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关键词

Q-TWiST,TWiST,health-related quality of life,metastatic pancreatic cancer,patient-centered outcomes

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