Population pharmacokinetics of amikacin in suspected cases of neonatal sepsis.

Nicolas Severino,Soledad Urzúa,Mauricio Ibacache,Claudio Paulos,Luis Cortínez,Alberto Toso,Liliana Leguizamon,Rocío Inojosa,Andrea Maccioni,Sebastián Meza,Andrés García,Marcelo Ramírez,Catalina Von Mentlen,Javiera Ceballos,Noemí Paredes

British journal of clinical pharmacology（2023）

引用 0|浏览6

暂无评分

摘要

Our main results confirm previous findings showing that weight, PMA and renal function are relevant factors influencing newborn amikacin pharmacokinetics. In addition, current results showed that pathophysiological states of critically ill neonates, such as sepsis and shock, were associated with opposite effects in amikacin clearance and should be considered in dose adjustments.

查看译文

关键词

antibiotics,infectious diseases,neonatology,paediatrics,pharmacometrics,sepsis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要