Low molecular weight heparin treatment reduced apoptosis and oxidative cytotoxicity in the thrombocytes of patients with recurrent pregnancy loss and thrombophilia: Involvements of TRPM2 and TRPV1 channels.

Yusuf Dal,Mustafa Nazıroğlu,Mehmet Okan Özkaya

The journal of obstetrics and gynaecology research（2023）

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摘要

The current study results suggest that the treatment of LMWH is useful against apoptotic cell death and oxidative toxicity in the thrombocytes of patients with RPL, which seem to be dependent on increased levels of [Ca ] concentration via the activation of TRPM2 and TRPV1.

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关键词

calcium signaling,low molecular weight heparin,oxidative cytotoxicity,recurrent pregnancy loss,thrombocytes

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