Thyrotropin inhibits osteogenic differentiation of human periodontal ligament stem cells.
Journal of periodontal research(2023)
摘要
Unless TSH is ≥10 mU/L, patients with subclinical hypothyroidism usually do not undergo thyroxine supplementation therapy. However, in this work, we found that elevated TSH inhibited the osteogenic differentiation of PDLSCs. Therefore, correction of TSH levels in patients with subclinical hypothyroidism may be beneficial to improve orthodontic, implant, and periodontitis outcomes in these patients.
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关键词
osteogenic differentiation,periodontal ligament stem cells (PDLSCs),subclinical hypothyroidism,thyrotropin
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