HER2 as a potential therapeutic target on quiescent prostate cancer cells

Kenji Yumoto, Jibraan Rashid, Kristina G Ibrahim,Steven P Zielske,Yu Wang,Maiko Omi,Ann M Decker,Younghun Jung,Dan Sun,Henriette A Remmer,Yuji Mishina,Laura A Buttitta,Russell S Taichman,Frank C Cackowski

Translational Oncology（2023）

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摘要

•Quiescent cells largely contribute to tumor progression, metastasis, and relapse.•Known quiescence markers are intracellular, not viable for antibody targeting.•Plasma membrane protein HER2 is upregulated in quiescent cells.•Drug conjugated anti-HER2 antibody delayed metastasis formation in mice.

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关键词

Dormancy,HER2,ERBB2,Quiescent,Prostate cancer,Disseminated tumor cells,Cell cycle,G0

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