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Induced epigenetic changes memorized across generations in mice

Cell(2023)

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摘要
Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.
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关键词
epigenetic changes,mice,generations,induced
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