Induced epigenetic changes memorized across generations in mice
Cell(2023)
摘要
Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.
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关键词
epigenetic changes,mice,generations,induced
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