3-Substituted Blatter Radicals: Cyclization of N -Arylguanidines and N -Arylamidines to Benzo[ e ][1,2,4]triazines and PhLi Addition.
The Journal of organic chemistry(2023)
Abstract
A series of 3-amino- and 3-alkyl-substituted 1-phenyl-1,4-dihydrobenzo[][1,2,4]triazin-4-yls was prepared in four steps involving N-arylation, cyclization of -arylguanidines and -arylamidines, reduction of the resulting -oxides to benzo[][1,2,4]triazines, and subsequent addition of PhLi followed by aerial oxidation. The resulting seven C(3)-substituted benzo[][1,2,4]triazin-4-yls were analyzed by spectroscopic and electrochemical methods augmented with density functional theory (DFT) methods. Electrochemical data were compared to DFT results and correlated with substituent parameters.
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Key words
cyclization
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