Integration of target, suspect, and nontarget screening with risk modeling for per- and polyfluoroalkyl substances prioritization in surface waters

•We identified 13 target and 20 nontarget PFAS in the Chaobai river.•A random forest regression model was developed to quantify nontarget PFAS.•The prediction errors of random forest regression model were ≤ 2.7 times.•The developed risk-based prioritization approach flagged 4 high risk PFAS.