Serial Genotyping of the Human Papillomavirus in Cervical Cancer: An Insight Into Virome Dynamics During Chemoradiation Therapy.

Julie Sammouri,Matthew C Wong,Erica J Lynn,Molly B El Alam,David K Lo,Daniel Lin, Timothy H Harris,Tatiana V Karpinets,Kyoko Court,Tatiana Cisneros Napravnik,Xiaogang Wu,Jianhua Zhang,Ann H Klopp,Nadim J Ajami,Lauren E Colbert

International journal of radiation oncology, biology, physics（2023）

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摘要

Rarer, less well-studied HPV types in cervical tumors are clinically significant. HPV 18 and HPV LR/negative tumors are associated with poor CRT response. This feasibility study provides a framework for a larger study of intratumoral HPV profiling to predict outcomes in patients with cervical cancer.

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human papillomavirus,cervical cancer,virome dynamics

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