Deconvolution of BNP and NT-proBNP Immunoreactivities by Mass Spectrometry in Heart Failure and Sacubitril/Valsartan Treatment.

Hélène Nougué,Thibault Michel,François Picard,Johan Lassus,Malha Sadoune,Said Laribi,Alain Cohen-Solal,Damien Logeart,Jean-Marie Launay,Nicolas Vodovar

Clinical chemistry（2023）

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摘要

Glycosylation interfered with NT-proBNPir measurement, explaining the discrepant evolution of these 2 biomarkers in patients receiving sacubitril/valsartan. Both BNPir and NT-proBNPir are surrogates of proBNP1-108 production, NT-proBNPir being more robust in the clinical contexts studied.

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关键词

mass spectrometry,heart failure,nt-probnp

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