IL-1 receptor antagonist attenuates proinflammatory responses to rhinovirus in airway epithelium.

Stephen A Schworer,Kelly D Chason,Gang Chen,Jie Chen,Haibo Zhou,Allison J Burbank,Matthew J Kesic,Michelle L Hernandez

The Journal of allergy and clinical immunology（2023）

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摘要

These data suggest that IL-1RA treatment significantly reduced proinflammatory cytokines while preserving the antiviral response. These results provide evidence for further investigation of IL-1RA as a novel targeted therapy against neutrophil-attractant cytokine release in RV-induced airway inflammatory responses.

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关键词

Asthma,IL-13,IL-1RA,anakinra,epithelial cells,exacerbations,rhinovirus

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