Neuropsychiatric and young-onset as clinical determinants for a delayed Huntington's disease diagnosis

Objective: This study aims to identify the possible factors that delay the time-to-diagnosis of Huntington's disease (HD). Methods: A cross-sectional study in HD patients was carried out. Variables registered were CAG repeats, age of onset, primary symptom at onset, age of molecular diagnosis, and time-to-diagnosis, among others. Results: 107 patients (50.5% female) with a mean age of 49 +/- 12.8 years (y) were included in the study. Median CAG size was 45 (38-73). Mean age of onset, mean age of molecular diagnosis, and mean time-to-diagnosis were 39 +/- 12.9, 45.1 +/- 12.1, and 6.4 +/- 6.4 years, res-pectively. In the comparative analysis, the neuropsychiatric-and the young-onset groups had a longer time-to-diagnosis than the motor-and typical-onset groups (p = 0.02 and p < 0.01, respectively). In the linear regression analysis, neuropsychia- tric-and young-onset were independent risk factors. Conclusions: Delayed diagnosis showed relation to neuropsychia- tric-and early-onset in HD.