Jiangchuanmycin, a New Pyrrolizidine Analog from Streptomyces sp. YIM S01863.
Chemistry & biodiversity(2023)
Abstract
Jiangchuanmycin (1), a new indole containing pyrrolizidine, and six known peptides (2-7) were obtained from the fermentation broth of a Streptomyces isolate collected from a sediment sample of Xingyun Lake, Jiangchuan, China. Their structures were elucidated on the detailed analysis of the HR-ESI-MS, 1D and 2D NMR, ECD, and X-ray crystallographic data. Jiangchuanmycin (1) presented weak inhibitory effects on cell lines of H1299, MHCC97H, HCT116 with the IC values of 97.6 μM, 98.6 μM and 40.6 μM, respectively.
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Key words
Streptomyces,actinomycetes,antitumor activity,indole,pyrrolizidine
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